Guilford is a town in Piscataquis County, incorporated on February 8, 1816 from the township T6 R7, NWP.
Formerly a grant to Bowdoin College, the land became available for settlement in about 1804 and in 1805 the first crops were grown and houses built.
Since several of the Low family had moved there, Lowstown became the locally applied name. In 1812 it was organized as a plantation. Soon the resident petitioned the Massachusetts General Court for incorporation as the town of Fluvanna. The proposed name was ignored in favor of Guilford.
The Piscataquis River flows through the main village with neighboring Sangerville on the southern shore. The town was long a center for textile production.
